By Stephen C. Harrison (auth.), Abner Louis Notkins M.D., Michael B. A. Oldstone M.D. (eds.)
The all new ideas in Viral Pathogenesis III comprises the commonly praised layout of featuring updated details in pithy, simply learn "mini-review" variety and enhances prior variants with contributions by way of prime overseas specialists on structure-function relationships, gene legislation, phone biology of viral infections, transgenic mice, expression of viral genes, retroviruses, and evolving suggestions in viral illnesses. Taken jointly, quantity I, II and III of Concepts in Viral Pathogenesis include one hundred forty five designated chapters every one representing the most recent pondering in vital parts of virology through the main investigators within the box. Clinicians, laboratory scientists, scholars, and others looking authoritative overviews of present wisdom at the mechanism of viral ailments will welcome this worthy resource.
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RACANIELLO Poliovirus is the causative agent of poliomyelitis, an acute disease of the central nervous system (eNS). For 50 years after its isolation in 1909, research on the virus was aimed at providing the necessary information on antigenic types, pathogenesis, and immunity so that vaccines could be developed. After two effective vaccines were produced, research on poliovirus turned toward understanding events that occur in infected cells, such as viral RNA and protein synthesis and inhibition of host macromolecular synthesis.
A similar recombinant, in which the 5' -noncoding region was derived from P3/Sabin and differed only by a U at base 472, was dramatically attenuated in mice . Therefore, the mouse model identifies mutations known to attenuate monkey intraspinal neurovirulence and can be used to identify regions of the P2/Sabin genome that attentuate P2/Lansing in mice. Recombinants were constructed in which segments of the P21 Lansing genome were replaced by homologous sequences from P2/P7I2, the attenuated parent of P2/Sabin.
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Concepts in Viral Pathogenesis III by Stephen C. Harrison (auth.), Abner Louis Notkins M.D., Michael B. A. Oldstone M.D. (eds.)