By C. Howe, J. E. Coward, T. W. Fenger (auth.), Hein Fraenkael-Conrat, Robert R. Wagner (eds.)
The time turns out ripe for a serious compendium of that section of the organic universe we name viruses. Virology, as a technological know-how, having handed only in the near past via its descriptive part of naming and num bering, has most likely reached that level at which quite few new really new-viruses should be came upon. prompted by way of the highbrow probes and methods of molecular biology, genetics, biochemical cytology, and excessive answer microscopy and spectroscopy, the sector has skilled a real info explosion. Few critical makes an attempt were made to chronicle those occasions. This entire sequence, in an effort to contain a few 6000 pages in a complete of approximately 18 volumes, represents a dedication by means of a wide crew of energetic investigators to investigate, digest, and expostulate at the nice mass of knowledge in relation to viruses, a lot of that is now amorphous and disjointed, and scattered all through a large literature. during this manner, we are hoping to put the complete box in point of view, and to improve an invalua ble reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered at any place, yet which additionally presents a logical development of constructing proof and built-in concepts.
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Extra info for Comprehensive Virology: Vol. 16: Virus-Host Interactions: Viral Invasion, Persistence, and Disease
An association has been reported between SOA and distinctive plaque morphology among SSPE isolates. , 1976). The genetic basis for expression of the SDA property was further substantiated by controlled nitrosoguanidine mutagenesis of conventional strains of virus. One strain was encountered which, while fully as infectious as the parental strains, showed only the SDA. In comparison to the wild-type virus, the nonhemagglutinating mutant strain adsorbed as well to susceptible cells, was equally neurovirulent for neonatal hamsters, and gave identical protein PAGE profiles.
Armentrout. Bar = 200 nm. Viral Invasion 19 tinal epithelial cells. It has been proposed that lactase, the concentrations of which are higher in young animals than in adult animals, might serve a dual function as both receptor and uncoating enzyme for rotaviruses, the major capsid protein of which (protein 7) is glycosylated. , 1976). Electron microscopic observations have been limited to infected intestinal columnar epithelium in intact animals and to limited extent in organ culture. Precise determination of the mode of entry into cells must await a satisfactory cell culture system in which the virus will replicate.
The central portion of the polypeptide is made up of hydrophobic amino acids which interact with the lipid bilayer. , 1978). An important interaction between spectrin and intramembranal particles (IMP) was brought to light by examining the effects of Sendai virus on human erythrocyte ghosts, which by themselves cannot be fused by virus. However, ghosts which had been loaded with bovine serum albumin (BSA) were susceptible to fusion by virus. Fusion of BSA ghosts was accompanied by release of BSA, presumably through sites at which viral envelope had fused with the membrane.
Comprehensive Virology: Vol. 16: Virus-Host Interactions: Viral Invasion, Persistence, and Disease by C. Howe, J. E. Coward, T. W. Fenger (auth.), Hein Fraenkael-Conrat, Robert R. Wagner (eds.)