By Shabir H. Lone, Khursheed Ahmad Bhat, Mohammad Akbar Khuroo
This e-book stories the chemical and organic homes of Artemisia amygdalina Decne, a significantly endangered and endemic plant species within the the high-altitude Kashmir Himalayas, which has a excessive pharmacological power. It describes the bioactivity-guided isolation of its chemicals, their characterization utilizing spectroscopic equipment and the advance of an easy and trustworthy RP-HPLC strategy for the simultaneous quantification of the remoted components. The authors talk about the aptitude pharmacological actions of A. amygdalina, resembling antioxidant, cytotoxic, anti inflammatory, immuno-modulatory and antidiabetic results, and pave the best way for destiny research.
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Extra info for Chemical and Pharmacological Perspective of Artemisia amygdalina
1). 93 µg mL−1), respectively, against TBA reactive species. 1). 11 µg mL−1), respectively. 1). Further, DNA damage was estimated using agarose gel assay. It has been found that damage to DNA has been reduced with an increase in concentrations of plant extracts (1000 µg mL−1). 6). (2013). Carrageenan-induced paw edema has been carried out to study the anti-inflammatory potential of A. 6 Agarose gel electrophoresis for DNA damage inhibition assay by A. amygdalina methanolic extracts. 2 Anti-inflammatory and Immunomodulatory Potential … 45 Decne.
The extracts were found to be safe up to the dose level of 2000 mg/kg of body weight in rats. The extracts did not induce any toxicological effect in any rat. There was no lethality found by oral administration of any extracts of A. amygdalina. 6 Antihyperglycaemic Effect of Artemisia amygdalina The effect of extracts of A. 5. 93 %). 09 % after 14 days of treatment. , petroleum ether and ethyl acetate, also showed inhibitory effect on glucose levels but were not considered for further studies.
The important biological activities that have been reported till date include those of free radical scavenging potential of the in vitro raised and greenhouse acclimatized plants, anti-inflammatory, and immunomodulatory activity of the plant and the anti-diabetic and anti-hyperlipidemic effect of A. amygdalina. 06 µg mL−1), respectively, against DPPH radical. Carrageenan paw edema model has been employed to study the potential of the plant extracts in inflammation in wistar rats. SRBC-specific haemagglutination-titer and DTH assays have been carried out in Balb/C mice for observing the effect of extracts on immune system.
Chemical and Pharmacological Perspective of Artemisia amygdalina by Shabir H. Lone, Khursheed Ahmad Bhat, Mohammad Akbar Khuroo