Download Bioorganic Chemistry: A Chemical Approach to Enzyme Action by Hermann Dugas PDF

By Hermann Dugas

ISBN-10: 1468400959

ISBN-13: 9781468400953

ISBN-10: 1468400975

ISBN-13: 9781468400977

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This is important when it is considered that proteins are built of amino acids, and so they may participate in acid-base chemistry in a manner which reflects their amino acid constituents. Indeed, our examinati,m of amino acid dissociation may, in a simplistic fashion, be regarded as that of a miniature protein model. Proteins playa functional role in biochemical reactions, so that such an analogy may provide a basis for understanding proton transfer processes. However, such a model may be too simple.

The reaction is catalyzed by the enzyme peptidyl transferase. It is the message carried by mRNA (which in tum is dictated by the genetic material DNA) which determines by specific interactions as to which aminoacyl-tRNA will bind at the P and A sites. 5 Biological Synthesis of Proteins of a new aminoacyl-tRNA to the aminoacyl site. Once this has occurred, peptide bond formation (to give a tripeptide) can take place, thus repeating the sequence of events as described (Fig. 1). This provides a basic description of in vivo protein synthesis, neglecting details such as the involvement of protein elongation factors.

Such is the basis for protein purification by isoelectric precipitation. The protein mixture is adjusted to a pH that is equivalent to the pIe ofthe desired protein, allowing the latter to precipitate out of the mixture. 5; it is lower for those amino acids with acidic side chains, and higher for those amino acids with basic side chains. On the other hand, for proteins it can range anywhere from pH equal 0 to 11. Derivation offormulas for the calculation of the pIi for amino acids is described in most biochemistry texts.

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Bioorganic Chemistry: A Chemical Approach to Enzyme Action by Hermann Dugas

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