By C. L. Kervran
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Additional info for Biological Transmutations
A probe trial can be introduced; the platform is removed and the areas searched and the number of crossings of the former platform location evaluated to assess search strategies. Reversal learning can be measured by moving the platform to another quadrant of the pool. , 1989; Shukitt-Hale, 1999). The platform location is changed each day. Performance in this version of the swim task primarily examines short-term working memory, based on scores on the second of each pair of trials. , 1995). These qualitative measures are not confounded by the motor abilities of the subjects.
Other factors may influence brain function indirectly by inhibiting or enhancing the transport of precursors of neurotransmitters across the blood-brain barrier. , 1999). Whether or not the bioactive ingredient crosses the blood-brain barrier, it will be important to identify the nutritional status that optimizes activity of the compound. One factor that may influence the response is the time of day that the ingredient is consumed. Many hormones and neurotransmitters have a circadian or pulsatile pattern of release.
As in the Morris water maze, the task promotes efficient learning and requires fewer days to complete testing as compared with the radial arm maze. fm Page 32 Tuesday, January 25, 2005 9:38 AM Testing in the radial arm water maze is generally conducted over 3 to 5 days (Hodges, 1996; Shukitt-Hale, 2004). On each trial, the rat is placed gently into the maze at the end of one of the arms that does not contain the platform. The trial ends when the animal finds the platform or at the end of 2 min.
Biological Transmutations by C. L. Kervran