By John D. Robertson, Joya Chandra, Vladimir Gogvadze (auth.), Patrick M. Dansette, Robert Snyder, Marcel Delaforge, G. Gordon Gibson, Helmut Greim, David J. Jollow, Terrence J. Monks, I. Glenn Sipes (eds.)
This quantity offers a dialogue of the organic results produced following the metabolism of xenobiotic chemical compounds to chemically reactive metabolites, i.e., poisonous and carcinogenic results, which were the root of all 5 prior volumes during this sequence. particularly, this quantity devotes sections to structure-activity relationships, contemporary advances within the realizing of the chemistry of reactive metabolites, and the iteration and task of reactive oxygen species with unique emphasis on nitric oxide. There also are segments on DNA harm by way of reactive metabolites and DNA fix, tissue particular responses to BRIs, and human health and wellbeing results of BRIs. The papers that include this quantity have been submitted through international type scientists who have been in attendance on the Symposium on organic Reactive Intermediates VI on the Université René Descartes, July 16-20, 2000.
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Extra info for Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases
90), by far the best correlation of any single parameter examined. 50) for the set of 9 haloacids when the 2 inactives are excluded. 29 for L'lE(X- loss). 55, respectively. This ability of the n=9 regression to extrapolate well beyond its range of modeled activity to predict very low activities for DFA and 2-FPA increases confidence in its validity. 0. 95 for 10g(A) vs. L'lE(MeS' conj) represents the most successful attempt to relate all 11 haloacids according to the same property metric. Another measure of success of this parameter correlation, however, is its ability to reproduce the correct relative orderings of activities within chemically meaningful subclasses of the data set.
Anders, M. , and Board, P. , 2000, Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis, Pharmacogenetics 10:49-57. Board, P. , Baker, R. , and Jermiin, L. , 1997, Zeta, a novel class of glutathione transferases in a range of species from plants to humans, Biochem. 1. 328:929-935. Bull, R. , Sanchez, I. , Nelson, M. , Larson, J. , and Lansing, A. , 1990, Liver tumor induction in B6C3Fl mice by dichloroacetate and trichloroacetate, Toxicol.
1. Monks. Formation of catechol estrogen glutathione conjugates and y-glutamyl transpeptidase-dependent nephrotoxicity of 17~-estradiol in the golden Syrian hamster. Carcinogenesis 18:561 (1997). 17. L. Viborg-Jorgensen, C. Cornett, U. H. O. Dragsted. Two-electron electrochemical oxidation of quercetin and kaempferol changes only the flavonoid C-ring. Free Rad. Res. 29: 339 (1998). 18. E. Sergediene, K. Jonsson, H. Szymusiak, B. M. Rietjens and N. Cenas, Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships.
Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases by John D. Robertson, Joya Chandra, Vladimir Gogvadze (auth.), Patrick M. Dansette, Robert Snyder, Marcel Delaforge, G. Gordon Gibson, Helmut Greim, David J. Jollow, Terrence J. Monks, I. Glenn Sipes (eds.)