Download Biochemical Aspects of Prostaglandins and Thromboxanes. by Norman Kharasch PDF

By Norman Kharasch

ISBN-10: 0124058507

ISBN-13: 9780124058507

ISBN-10: 032315851X

ISBN-13: 9780323158510

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Additional info for Biochemical Aspects of Prostaglandins and Thromboxanes. Proceedings of the 1976 Intra-Science Research Foundation Symposium December 1–3, Santa Monica, California

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Natl . Acad . Sci . US A 73, 173 0 (1976) . Polsky-Cynkin , R. L. , an d Levine , L. , J . Pharmacol . Exper . Therapeu . 197 , 56 7 (1976) . S. L. , an d Levine , L. , J . Biol . Chem. i n pres s (1977) . S. , an d Levine , L. , Prostaglandin s 12 , 80 3 (1976) . S. , an d Levine , L. , Prostaglandin s 13 , 6 5 (1977) . Tarn , S. L. , an d Levine , L. , submitte d fo r publication . K. B. J. , Biochim . Biophys . Act a 424 , 30 3 (1976) . M . D. , Terragno , Á. -K. , Fed . Proc . 35 , 17 5 (1976) .

Thus , th e mas s spectru m o f a fractio n elutin g befor e di-no r PGFi a i s presente d i n Figur e 6 (fractio n III) . Not e th e similarit y o f th e spectra , majo r peak s bein g foun d i n bot h spectr a a t m/ e = 543 , 487 , 468 , 398 , 378 , 352 , 307 , 282 , 217 , an d 191 . Th e mas s spectra l dat a thu s suggest s tha t di-no r PGF a an d stereoisomer s ar e forme d i n th e fre e radica l cyclization . Th e tota l yiel d o f product s havin g mas s spectr a simila r t o di-no r PGF a i s 5-7% .

Arachidoni c aci d i s presen t i n th e MC5- 5 cell s mostl y a s 36 Lawrenc e Levin e et al. phospholipids . I n orde r t o provid e substrat e fo r th e cyclo oxygenase , deacylatio n o f th e phospholipid s i s mandatory . I n additio n t o th e direc t effec t o n th e prostaglandi n cyclooxy genase , ther e ar e severa l othe r pathway s tha t coul d b e affecte d b y thes e inhibitors . Suc h pathway s include : 1 ) indirec t activatio n o f phospholipase , analogou s t o th e polypeptid e releasin g facto r tha t activate s th e phospholipas e i n anaphylaxi s (19) , 2 ) a direc t effec t o n th e phospholipase , and 3 ) transpor t o f th e arachidoni c acid , afte r deacylation , t o th e cyclooxygenas e (Tabl e 6 ) .

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Biochemical Aspects of Prostaglandins and Thromboxanes. Proceedings of the 1976 Intra-Science Research Foundation Symposium December 1–3, Santa Monica, California by Norman Kharasch


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