By Victor R Preedy, Hideyuki Hayashi, Bernard Do, M H Ahmed, Lucien Bettendorff, K Shibata, T Fukuwatari, Dorla L Lildballe, T Yagi, Micheal Rychlik, C Sanchez-Moreno, R Agarwal, Faruk Ahmed, John R Guyton, F Bamonti, R Prakash, Jutta Dierkes, C Antoniades,
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Extra info for B Vitamins and Folate: Chemistry, Analysis, Function and Effects
1935). 3). 3), was discovered by Warburg and Christian and independently by a rival group led by Hans von Euler-Chelpin, a notable student of Warburg’s father, Emil Warburg (Schlenk and von Euler 1936; Warburg and Christian 1936). G. Knight found that nicotinic acid is a Staphylococcus growth factor. Inspired probably by these ﬁndings, Elvehjem and associates were able to cure black-tongue disease, a dog counterpart of pellagra, by administering nicotinic acid (Elvehjem et al. 1937). There remained, however, a mystery: diet that induced black tongue in dogs was richer in nicotinic acid or its amide than normal milk.
Biochemische Zeitschrift. 282: 157–165. , 1936. Pyridin, der wasserstoﬀu¨bertragende Bestandteil von Ga¨rungsfermenten (Pyridin-Nucleotide). Biochemische Zeitschrift. 287: 291–328. , 1938. Isolierung der prosthetischen Gruppe der d-Aminosa¨ureoxydase. Biochemische Zeitschrift. 298: 150–155. , 1906. The importance of individual amino acids in metabolism; observations on the eﬀect of adding tryptophan to a dietary in which zein is the sole nitrogenous constituent. Journal of Physiology. 35: 88–102.
However, since they are recycled, they are not usual substrates and share ‘reusability’ as a common property with other catalytic coenzymes. Today, the catalytic mechanisms of coenzymes are understood in detail. However, only few, namely those of folic acid and vitamin B12, can explain the symptoms of their deﬁciency. With regard to beriberi, our knowledge has not much improved since the time of Takagi and Eijkman. Certainly, B vitamins have functions other than those as coenzymes. The discovery of NADdependent ADP ribosylation was, in this sense, a breakthrough.
B Vitamins and Folate: Chemistry, Analysis, Function and Effects by Victor R Preedy, Hideyuki Hayashi, Bernard Do, M H Ahmed, Lucien Bettendorff, K Shibata, T Fukuwatari, Dorla L Lildballe, T Yagi, Micheal Rychlik, C Sanchez-Moreno, R Agarwal, Faruk Ahmed, John R Guyton, F Bamonti, R Prakash, Jutta Dierkes, C Antoniades,