By Sandra Perez, Peter Eichhorn, Damia Barcelo
Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, foodstuff, Doping, and Forensic Analysis bargains with using high-resolution mass spectrometry (MS) within the research of small natural molecules. during the last few years, time-of-flight (ToF) and Orbitrap MS have either skilled great development in numerous analytical sectors and are actually good demonstrated in lots of laboratories the place excessive necessities are put on analytical functionality.
This e-book provides a head-to-head comparability of those applied sciences that compete at once with one another. As clients with hands-on adventure in either innovations, the authors supply a balanced description of the strengths and weaknesses of either strategies. within the overwhelming majority of circumstances, ToF-MS and Orbitrap-MS were used for qualitative reasons, typically id of discrete molecular entities resembling drug metabolites or transformation items of environmental contaminants.
This paradigm is now altering as quantitative services are more and more being explored, as are non-target ways for impartial broad-scope screening. In view of the continual innovation of high-resolution MS tool brands in designing and constructing extra robust machines, technological advances in either and software program are substantial, with many novel functions.
This e-book summarizes and analyzes those developments. The compilation of chosen examples from assorted analytical fields will permit the readers to find not just the opportunity of high-resolution MS of their area, but in addition indicates advances in different fields that depend upon hi-res MS.
- Provides accomplished assurance of purposes of time-of-flight and orbitrap mass spectrometry in environmental, nutrients, doping, and forensic analysis
- Explores various really good options, giving a balanced description of the strengths and weaknesses of each
- Presents a basic evaluation of imaging ideas inside analysis
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Extra resources for Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis
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In early 2009, both Waters and Bruker introduced optional GC-APCI sources compatible with their LC/MS products. Agilent followed in 2011. Product literature highlights the benefits of increased pseudo molecular ion intensity in comparison to EI in support of increased sensitivity. The need for fragment ion confirmation was also achieved through the use of either in-source or collision-cell collisional induced dissociation (CID). One recent report evaluated the potential of GC-APCI-TOF for the analysis of pesticides residues in fatty matrices .
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Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis by Sandra Perez, Peter Eichhorn, Damia Barcelo