By Donna H. Wang
Donna Wang and a panel of hands-on specialists describe in step by step element all of the significant molecular, biochemical, and practical innovations now utilized in probing the renin-angiotensin process. those variety from using embryonic gene focusing on to create of mutant traces, to the useful research of parts of the renin-angiotensin method. accomplished and hugely sensible, Angiotensin Protocols interprets specialist wisdom into with no trouble reproducible tools that permit all biomedical investigators effectively to discover the position of angiotensin in well-being and disorder at the present time.
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Albert Szent-Gyorgyi Acknowledgments The author wishes to acknowledge, with great appreciation, the many investigators whose pioneering work he was unable to reference because of space limitations. This research was supported by a grant from the National Heart, Lung and Blood institute (PO1 HL 51971). 18 Hall References 1. Aurell, M. (1998) The renin-angiotensin system—the centenary jubilee. Blood Pressure 7, 71–75. 2. Page, I. H. (1987) Hypertension Mechanisms. Grune & Stratton, Orlando, FL. 3.
Three Angiotensin Paradigms in One Patient 33 The latter effect leads to increased deposition of collagen I and III, fibronectin, vitronectin, and laminin (24), and other components of intercellular matrix. Multiple intracellular mediators for these actions of Ang II have been uncovered, such as TGF-beta (27), PDGF (28), nuclear factor-kappa B (29), and VEGF (30). , stimulation of PAI-1) may also contribute via local thrombosis of the microcirculation (31). MAP kinase signal transduction pathways and overexpression of proto-oncogenes (32) participate in Ang II-stimulation of glomerular cell growth and proliferation.
Bahkle, Y. S. (1968) Conversion of angiotensin I to angiotensin II by cell–free extracts of dog lung. Nature 220, 919–921. 61. Ondetti, M. , Williams, N. , Sabo, E. , Weaver, E. , and Kocy, O. (1971) Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure and synthesis. Biochemistry 10, 4033–4039. 62. Ondetti, M. , and Cushman, D. V. (1977) Design of specific inhibitors of angiotensin converting enzyme: new class of orally active antihypertensive agents.
Angiotensin Protocols (Methods in Molecular Medicine) by Donna H. Wang