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144 Four types of KS have been described: classic, endemic or African, posttransplant or iatrogenic, and AIDS-associated KS. 159–161 HHV-8 PATHOGENESIS IN KS Multiple factors contribute to the development of KS. 162,163 Since the discovery of HHV-8, there have been a large number of studies evaluating its underlying role in KS. 165 found that the risk of developing disease increased with HHV-8 antibody titers. 166–169 HHV-8 has been shown to have certain genes to be homologous to cyclin D1 and G-protein coupled receptors, which are known to contribute to oncogenesis.

264 However, overall it was found that PELs exhibit a restricted pattern of EBV latency, lacking significant expression of most of the major EBV growth transforming factors. It is likely, with this background, that HHV-8 has a significant role in the pathogenesis of PELs. 2 months among HIV-infected individuals. Prior reported median survival was shorter than 6 months, and a poor performance status and absence of HAART before PEL diagnosis was found to be independently associated with a weaker clinical outcome in the French study.

31 Methotrexate administered intravenously is able to penetrate the blood–brain barrier and achieve levels high enough to be cytotoxic. In non-AIDS-related PCNSL, using methotrexate with radiation therapy (RT) and other chemotherapy regimens demonstrated a significant survival prolongation compared with RT alone. 34 TREATMENT AND SURVIVAL OF AIDS-ASSOCIATED PCNSL Radiation The standard treatment of patients with AIDS-related CNS lymphoma is palliative whole-brain radiation. 37 Chemotherapy (Table 1)38 In AIDS-related PCNSL, there is no optimum regimen of chemotherapy.

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AIDS-Associated Viral Carcinogenesis by C. Meyers

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