Download Advanced nutrition by Carolyn D Berdanier PDF

By Carolyn D Berdanier

ISBN-10: 0849326648

ISBN-13: 9780849326646

ISBN-10: 0849385008

ISBN-13: 9780849385001

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Sample text

These are of the w9 series of fatty acids. Fatty acid elongation and desaturation of the w9 series in the endoplasmic reticulum essentially stops with the formation of 22:3w9. In the w7 series, elongation stops at 18:3w7. The w6 series ends with the formation of arachidonate, while the w3 series continues on up to the formation of 22:6w3. In the endoplasmic reticulum, the reaction sequence is similar to that described for the cytosolic fatty acid synthase complex. The source of the 2-carbon unit is malonyl CoA and NADPH provides the reducing power.

As a corollary, one might also anticipate that the consumption of a high-glucose, lowfat diet that stimulates insulin release and also provides ample glucose for conversion to fatty acids would be characterized by high rates of lipogenesis, particularly in the liver. In rodents, this anticipation is justified. However, in humans, there is some discussion as to whether the human diet is sufficiently high in simple sugar and sufficiently low in fat to have the same sort of lipogenic response. Further, phosphorylated sugars have allosteric effects on this enzyme complex.

This means that glycogenolysis never fully depletes the cell of its glycogen content. 6). It is called a cascade because of the stepwise changes in activation states of the enzymes involved. To release glucose for oxidation by the glycogenolytic pathway, the glycogen must be phosphorylated. This is accomplished by the enzyme glycogen phosphorylase, which exists in the cell in an inactive form (glycogen phosphorylase b) and is activated to its active form (glycogen phosphorylase a) by the enzyme phosphorylase b kinase.

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Advanced nutrition by Carolyn D Berdanier


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