Download A Practical Guide to Cluster Randomised Trials in Health by Sandra Eldridge PDF

By Sandra Eldridge

ISBN-10: 0470510471

ISBN-13: 9780470510476

ISBN-10: 1119966248

ISBN-13: 9781119966241

Cluster randomisedtrials are trials within which teams (or clusters) of people are randomly allotted to assorted different types of therapy. In future health care, those trials frequently evaluate other ways of coping with a disorder or selling fit residing, unlike traditional randomised trials which randomise contributors to assorted remedies, classically evaluating new medicines with a placebo. they're more and more universal in well-being companies examine. This publication addresses the statistical, sensible, and moral matters coming up from allocating teams of people, or clusters, to various interventions.

 Key features: 

  • Guides readers in the course of the levels of undertaking an ordeal, from recruitment to reporting.
  • Presents quite a lot of examples with specific emphasis on trials in wellbeing and fitness companies examine and first care, with either rules and strategies defined.
  • Topics are in particular offered within the order during which investigators take into consideration matters after they are designing an ordeal.
  • Combines details at the most up-to-date advancements within the box including a pragmatic consultant to the layout and implementation of cluster randomised trials.
  • Explains rules and methods via quite a few examples together with many from the authors personal event.
  • Includes quite a lot of references if you happen to desire to learn further. 

This publication is meant as a realistic consultant, written for researchers from the overall healthiness professions together with medical professionals, psychologists, and allied healthiness execs, in addition to statisticians eager about the layout, execution, research and reporting of cluster randomised trials. people with a extra common curiosity will locate the ample examples illuminating.

Chapter 1 creation (pages 1–21):
Chapter 2 Recruitment and Ethics (pages 22–43):
Chapter three Designing Interventions (pages 44–59):
Chapter four Pilot and Feasibility experiences (pages 60–73):
Chapter five layout (pages 74–98):
Chapter 6 research (pages 99–136):
Chapter 7 pattern measurement Calculations (pages 137–171):
Chapter eight The Intra?Cluster Correlation Coefficient (pages 172–195):
Chapter nine different issues (pages 196–217):
Chapter 10 Trial Reporting (pages 218–265):

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Extra info for A Practical Guide to Cluster Randomised Trials in Health Services Research

Example text

Bennett, C. et al. (2008) Internal and external validity of cluster randomised trials: systematic review of recent trials. BMJ, 336 (7649), 876–880. , Torgerson, D. et al. (2005) Differential recruitment in a cluster randomized trial in primary care: the experience of the UK back pain, exercise, active management and manipulation (UK BEAM) feasibility study. Clin. Trials, 2 (2), 119–124. , Highton, C. et al. (1995) Do clinical guidelines introduced with practice based education improve care of asthmatic and diabetic patients?

Much of the early work on cluster randomised trials by Donner (Donner, Birkett and Buck, 1981) used the ICC, and sample size calculations within health services research also usually use it. The ICC is the measure on which we shall concentrate in this book. Other methods of estimating the between-cluster variation are the betweencluster variance (Cornfield, 1978), often denoted by σ b2 , or the between-cluster coefficient of variation of the outcome (σb/μ) (Hayes and Bennet, 1999), where μ represents the mean outcome across all clusters.

Isaakidis, P. P. (2003) Evaluation of cluster randomized controlled trials in sub-Saharan Africa. Am. J. , 158, 921–926. , Sharp, S. et al. (1999) Randomised controlled trial of follow up care in general practice of patients with myocardial infarction and angina: final results of the Southampton heart integrated care project (SHIP). BMJ, 318 (7185), 706–711. , Woods, A. et al. (2005) Promoting child safety in primary care: a cluster randomised controlled trial to reduce baby walker use. Br. J. Gen.

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A Practical Guide to Cluster Randomised Trials in Health Services Research by Sandra Eldridge

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